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TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE

CAS: 149771-43-7

Molecular Formula: C18H26N2O2

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TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE - Names and Identifiers

Name TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
Synonyms 3-Benzyl-8-Boc-3,8-diaza-bicyclo[3.2.1]octane
TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 3-(phenylMethyl)-, 1,1-diMethylethyl ester
CAS 149771-43-7

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE - Physico-chemical Properties

Molecular FormulaC18H26N2O2
Molar Mass302.41
Storage Condition2-8°C
UseUses 3-benzyl-8-(tert-butoxycarbonyl)-3, 8-diazabicyclo [3.2.1]-octane is a hydrocarbon derivative, which can be used as a pharmaceutical intermediate.

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE - Upstream Downstream Industry

Raw MaterialsD-Proline, 1-(phenylmethyl)-5-[[(phenylmethyl)amino]carbonyl]-, ethyl ester, (5S)-
3-BENZYL-3,8-DIAZABICYCLOOCTANE[3.2.1]-2,4-DIONE
3,8-dibenzyl-3,8-diazabicyclo[3.2.1]octane-2,4-dione
Diethyl meso-2,5-dibromoadipate
8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE
(1-Benzylpyrrolidine-2,5-diyl)diMethanol
1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE
tert-butyl 2,5-bis(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate
diethyl 1-benzylpyrrolidine-2,5-dicarboxylate
3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE
DIETHYL 1-BENZYLPYRROLIDINE-2,5-DICARBOXYLATE
Benzaldehyde
Di-tert-butyl dicarbonate
Sodium bicarbonate
Benzyl bromide

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE - Preparation

3, 8-diazabicyclo [3.2.1] octane -8-formic acid tert-butyl ester (0.5g,2.4mmol), benzyl bromide (0.31mL,2.6mmol) and triethylamine (0.5 ml,3.6mmol) were sequentially added into a 100mL single-mouth bottle, dissolved with acetonitrile (20mL), and gradually heated to 50 ℃ for 5 hours under nitrogen protection. The reaction solution is cooled to room temperature and then poured into tap water, ethyl acetate is extracted (60mL × 3), and the organic phase is then washed with tap water, saturated salt water, and dried with anhydrous sodium sulfate. The crude product was obtained by filtration and evaporation, and purified by column chromatography (petroleum ether/ethyl acetate (v/v)= 40/1-20/1) to obtain 3-benzyl -8-(tert-butoxycarbonyl)-3, 8-diazabicyclo [3.2.1]-octane as a white solid (0.68g,90%).

Last Update：2024-04-10 22:29:15

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE - Reference Information

use 3-benzyl -8-(tert-butoxycarbonyl)-3,8-diazabicyclo [3.2.1]-octane is a hydrocarbon derivative and can be used as a pharmaceutical intermediate.
preparation 3,8-diazabicyclo [3.2.1] octane -8-tert-butyl formate (0.5g,2.4mmol), benzyl bromide (0.31mL,2.6mmol), triethylamine (0.5
ml,3.6mmol) was sequentially added into a 100mL single-mouth bottle, dissolved with acetonitrile (20mL), and gradually heated to 50 ℃ under nitrogen protection for 5
hours. The reaction solution is cooled to room temperature and then poured into tap water, ethyl acetate is extracted (60mL × 3), and the organic phase is then washed with tap water, saturated salt water, and dried with anhydrous sodium sulfate. The crude product was obtained by filtration and evaporation, and purified by column chromatography (petroleum ether/ethyl acetate (v/v)= 40/1-20/1) to obtain 3-benzyl -8-(tert-butoxycarbonyl)-3, 8-diazabicyclo [3.2.1]-octane as a white solid (0.68g,90%).
Last Update：2024-04-09 19:05:04
TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 149771-43-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE Visit Supplier Webpage Request for quotation
CAS: 149771-43-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
Raw Materials for TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
3-BENZYL-3,8-DIAZABICYCLOOCTANE[3.2.1]-2,4-DIONE
3,8-dibenzyl-3,8-diazabicyclo[3.2.1]octane-2,4-dione
8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE
(1-Benzylpyrrolidine-2,5-diyl)diMethanol
diethyl 1-benzylpyrrolidine-2,5-dicarboxylate
3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE
DIETHYL 1-BENZYLPYRROLIDINE-2,5-DICARBOXYLATE
Benzaldehyde
Di-tert-butyl dicarbonate
Sodium bicarbonate
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